Porphyromonas gingivalis Synthase Demonstrate Impaired Killing of Mice Lacking Inducible Nitric Oxide
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Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis.
Porphyromonas gingivalis is a primary etiological agent of generalized severe periodontitis, and emerging data suggest the importance of reactive oxygen and nitrogen species in periodontal tissue damage, as well as in microbial killing. Since nitric oxide (NO) released from inducible NO synthase (iNOS) has been shown to possess immunomodulatory, cytotoxic, and antibacterial effects in experimen...
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